Original articles

136. Kruger, J., Sus, N., Moser, A., Scholz, S., Adler, G., Venturelli, S. & Frank, J. (2024) Low β-carotene bioaccessibility and bioavailability from high fat, dairy-based meal. Eur J Nutr (published online), IF 4.1.

135. Schoissengeier, V., Maqboul, L., Weber, D., Grune, T., Bürkle, A., Moreno-Villaneuva, M., Franceschi, C., Capri, M., Bernhard, J., Toussaint, O., Debacq-Chainiaux, F., Weinberger, B, Gonos, E. S., Sikora, E., Dollé, M., Jansen, E., Slagboom, P. E., Hervonnen, A., Hurme, M., Breusing, N., Frank, J., Bulmer, A. C. & Wagner, K. H. (2024) Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort. iScience 27: 110234, IF 5.8.

134. Kasapoğlu, K. N., Sus, N., Kruger, J., Frank, J. & Özçelik, B. (2024) Fabrication of phenolic loaded spray-dried nanoliposomes stabilized by chitosan and whey protein: Digestive stability, transepithelial transport and bioactivity retention of phenolics. Int J Biol Macromol (published online), IF 8.2.

133. Eleraky, L., Stuetz, W., Rybak, C., Frank, J., Biesalski, H. K., Mbwana, H., Kinabo, J. & Lambert, C. (2024) Potentials and limitations of a food group-based algorithm to assess dietary nutrient intake of women in rural areas in Tanzania. Int J Food Sci Nutr 75: 436-444, IF 4.1.

132. Montoya-Arroyo, A., Brand, V., Kröpfl, A., Vetter, W. & Frank, J. (2024) Metabolism of 11'-α- and 11'-γ-tocomonoenols in HepG2 cells favors the γ-congener and results predominantly in carboxymethylbutyl-hydroxychromans. Mol Nutr Food Res 68: 2300657, IF  5.2.

131. Brenner, M. B., Wüst, M., Frank, J. & Wagner K. G. (2024) In vivo predictive dissolution of the lipophilic phytochemicals trans-resveratrol, coenzyme Q10 and quercetin. J Drug Deliv Sci Technol 105561, IF. 5.0.

130. Kasapoğlu, K. N., Gültekin-Özgüven, M., Kruger, J., Frank, J., Bayramoğlu, P., Barla-Demirkoz, A. & Özçelik, B. (2024) Effect of spray drying on physicochemical stability and antioxidant capacity of Rosa pimpinellifolia fruit extract-loaded liposomes conjugated with chitosan or whey protein during in vitro digestion. Food and Bioprocess Technology (published online), IF 5.6.

129. Lauer, L. A., Mieres-Castro, D., Schmale, V., Frank, J. & Jiménez-Aspee, F. (2024) Cytoprotective effects of iridoids from Gaultheria spp. berries in gastric and intestinal epithelial cells after in vitro digestion. Food Bioscience 57: 103587, IF 5.2.

128. Almasri, F., Collotta, D., Aimaretti, E., Sus, N., Aragno, M., Dal Bello, F., Eva, C.,  Mastrocola, R., Landberg, R., Frank, J., & Collino, M. (2024) Dietary intake of fructooligosaccharides protects against metabolic derangements evoked by chronic exposure to fructose or galactose in rats. Mol Nutr Food Res 68: 2300476, IF 6.575.

127. Pospiech, J., Hoelzle, E., Schoepf, A., Melzer, T., Granvogl, M. & Frank, J. (2024) Acrylamide increases and furanoic compounds decrease in plant-based meat alternatives during pan-frying. Food Chemistry 439: 138063, IF 8.8.

126. Montoya-Arroyo, A., Muñoz-González , A., Lehnert, K., Frick, K., Schmid-Staiger, U., Vetter, W. & Frank, J. (2024) Monodopsis subterranea is a source of α-tocomonoenol and its concentration, in contrast to α-tocopherol, is not affected by nitrogen depletion. Food Science & Nutrition 12: 1869-1879, IF 3.9.

125. Beitze, D. E., Kavira Malengera, C., Barhwamire Kabesha, T., Frank, J. & Scherbaum, V. (2023) Disparities in health and nutrition between semi-urban and rural mothers and birth outcomes of their newborns in Bukavu, DR Congo: a baseline assessment. Primary Health Care Research & Development 24(e61): 1-18, IF 1.6. 

124. Brenner, M. B., , Flory, S., Wüst, M., Frank, J., & Wagner, K. (2023) A novel biphasic in vitro dissolution method correctly predicts the oral bioavailability of curcumin in humans. J Agric Food Chem 71: 15632-15643, IF 6.1.

123. Buckett, L., Sus, N., Spindler, V., Rychlik, M., Schoergenhofer, C. & Frank, J. (2023) The pharmacokinetics of individual conjugated xanthohumol metabolites show efficient glucuronidation and higher bioavailability of micellar than native xanthohumol in a randomized, double-blind, crossover trial in healthy humans. Mol Nutr Food Res 67: 2200684, IF 6.575.

122. Nina, N., Theoduloz, C., Paillán, H., Jiménez-Aspee, F., Márquez, K, Schuster, K., Becker, L., Oellig, C., Frank, J.  & Schmeda-Hirschmann, G. (2023) Chemical profile and bioactivity of Chilean bean landraces (Phaseolus vulgaris L.). J Funct Foods 114: 105513, IF 5.223.

121. Kasapoğlu, K.N., Kruger, J., Barla-Demirkoz, A., Gültekin-Özgüven, M., Frank, J. & Özçelik, B. (2023) Optimization of supercritical carbon dioxide extraction of (poly)phenols from black rosehip and their bioaccessibility using an in vitro digestion/Caco-2 cell model. Foods 12: 781, IF 5.561.

120. Jeremias, T., Abou-Rizk, J., Burgard, L., Entenmann, I., Nasreddine, L., Jomaa, L., Hwalla, N., Frank, J. & Scherbaum, V. (2023) Anemia among Syrian Refugee Children aged 6 to 23 months living in Greater Beirut, Lebanon, including the Voices of Mothers’ and Local Healthcare Staff: a mixed-methods study. Nutrients 15: 700, IF 6.706.

119. Stiefvatter, L., Frick, K., Lehnert, K., Vetter, W., Montoya-Arroyo, A., Frank, J., Schmid-Staiger, U. & Bischoff, S. C. (2022) Potentially beneficial effects on healthy aging by supplementation of the EPA-rich microalgae Phaeodactylum tricornutum or its supernatant – a randomized controlled trial in elderly individuals. Marine Drugs 20: 716, IF  6.085.

118. Abou-Rizk, J., Jeremias, T., Nasreddine, L., Jomaa, L., Hwalla, N., Frank, J. & Scherbaum, V. (2022) Supporting factors and barriers related to early initiation ofbreastfeeding and exclusive breastfeeding among infants of Syrian refugees inGreater Beirut, Lebanon: a mixed methods study. Nutrients 14: 4459, IF 6.706.

117. Kasapoğlu, K.N., Demircan, E., Gültekin-Özgüven, M., Kruger, J., Frank, J., Arslaner, A. & Özçelik, B. (2022) Recovery of polyphenols using Pressurized Hot Water Extraction (PHWE) from black rosehip followed by encapsulation for increased bioaccessibilityand antioxidant activity. Molecules 27: 6807, IF 4.927.

116. Jiménez-Aspee, F., Pospiech, J., Bauer, S., Sus, N., Kufer, T. and Frank, J. (2023) Prumnopitys andina fruit extract activates liver X receptors after in vitro digestion. Mol Nutr Food Res 67: 2200377, IF 5.914.

115. Grafeneder, J., Derhaschnig, U., Eskandary, F., Buchtele, N., Sus, N., Frank, J., Jilma, B. & Schoergenhofer, C. (2022) Micellar curcumin: Pharmacokinetics and effects on inflammation markers and PCSK-9 concentrations in healthy subjects in a double-blind, randomized, active-controlled, crossover trial. Mol Nutr Food Res 66: 2200139, IF 5.914.

114. Omar, N. A., Dicksved, J., Kruger, J.,Zamaratskaia, G., Michaelsson, K., Wolk, A., Frank, J. & Landberg, R. (2022) Effect of a diet rich in galactose or fructose, with or without fructooligosaccharides, on gut microbiota composition in rats. Frontiers in Nutrition 9: 922336, IF 6.590.

113. Eleraky, L., Issa, R., Maciel, S., Mbwana, H., Rybak, C., Frank, J. & Stuetz, W. (2022) Anthropometrics, hemoglobin status and dietary micronutrient intakeamong Tanzanian and Mozambican pigeon pea farmers. Nutrients 14: 2914, IF 6.706.

112. Zhu, Y., Frank, J., Riphagen,I. J., Minovic, I., Vos,M. J., Eggersdorfer, M. L., Navis, G. J. & Bakker,S. J. L. (2022) Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: The Lifelines-MINUTHE Study. Eur J Nutr 61: 3755–3765, IF 5.619.

111. Nir, D., Ribarski-Chorev, I., Shimoni, C., Strauss, C., Frank, J. & Schlesinger, S. (2022) Antioxidants attenuate heat-shock induced premature senescence of bovine mesenchymal stem cells. Int J Mol Sci 23: 5750, IF 5.924.

110. Montoya-Arroyo, A., Toro-Gonzáles, C., Sus, N., Warner, J., Esquivel, P., Jiménez, V. M. & Frank, J. (2022) Vitamin E and carotenoid profiles in leaves, stems, petioles and flowers of stinging nettle (Urtica leptophylla Knuth) from Costa Rica. J Sci Food Agric 102: 6340-6348, IF 3.639.

109. Esselun, C., Dieter, F., Sus, N., Frank, J. & Eckert, G. P. (2022) Walnut Oil Reduces Aβ Levels and Increases Neurite Length in aCellular Model of Early Alzheimer Disease. Nutrients 14: 1694, IF 6.706.

108. Buckett, L., Schönberger, S., Spindler, V., Sus, N., Schoergenhofer, C., Frank, J., Frank, O., & Rychlik, M. (2022) Synthesis of human phase I and phase II metabolites of hop (Humuluslupulus) prenylated flavonoids. Molecules 12: 345, IF 4.927.

107. Keller, M., Kreuzer, M., Reidy, B., Scheurer, A., Guggenbühl, B., Luder, M., Frank, J. & Giller, K. (2022)Effects on performance, carcass and meat quality of replacing maize silage and concentrate by grass silage and corn-cob mix in the diet of growing bulls. Meat Science 188: 108795, IF 5.209.

106. Flory, S., Benz, A.-K. & Frank, J. (2022) Uptake and time-dependent subcellular localization of native and micellar curcumin in intestinal cells. BioFactors 48: 897-907, IF 6.113.

105. Montoya-Arroyo, A., Lehnert, K., Muñoz-González, A., Schmid-Staiger, U., Vetter, W. & Frank, J. (2022) Tocochromanol profiles in Chlorella sorokiniana, Nannochloropsislimnetica and Tetraselmis suecica confirm the presence of 11'-α-tocomonoenol in cultured microalgae independently of species and origin. Foods 11: 396, IF 4.350.

104. Lux, P. E., Fuchs, L., Wiedmaier-Czerny, N. & Frank, J. (2022) Oxidative stability of tocochromanols, carotenoids, and fatty acids in maize (Zea mays L.) porridges with varying phytate concentrations during cooking and in vitro digestion. Food Chem 378: 132053, IF 7.514.

103. Stiefvatter, L., Lehnert, K., Frick, K.,Montoya-Arroyo, A., Frank, J., Vetter, W., Schmid-Staiger, U. & Bischoff, S. C. (2021) Oral bioavailability of omega-3 fatty acids and carotenoids from themicroalgae Phaeodactylum tricornutum in healthy young adults. Marine Drugs 19: 700, IF 5.118.

102. Montoya-Arroyo, A., Lehnert, K., Lux, P. E., Jiménez, V., Esquivel, P., Silva-Benavides, A. M., Vetter, W. & Frank, J. (2021) 11'-α-Tocomonoenol is the major α-tocomonoenol isomer in cyanobacteria and microalgae from Costa Rica. J Food Compos Anal 107: 104325, IF 4.556.

101. Abou-Rizk, J., Jeremias, T., Cocuz, G., Nasreddine, L., Jomaa, L., Hwalla, N., Frank, J. & Scherbaum, V. (2021) Food insecurity, low dietary diversity, and poor mental health among Syrian refugee mothers living in vulnerable areas of Greater Beirut, Lebanon. Brit J Nutr 128: 1832-1847, IF 3.718.

100. Flory, S., Männle, R. & Frank, J. (2021) The inhibitory activity of curcumin on P-glycoprotein and its uptake by and efflux from LS180 cells is not affected by its galenic formulation. Antioxidants10: 1826, IF 7.675.

99. Stokes, C. S., Weber, D., Wagenpfeil, S., Stuetz, W., Moreno-Villanueva, M., Dollé, M. E. T., Jansen, E., Gonos, E. S., Bernhardt, J., Grubeck-Loebenstein, B., Fiegl, S., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Capri, M., Hervonen, A., Slagboom, P. E., Breusing, N., Frank, J., Bürkle, A., Franceschi, C. & Grune, T. (2021) Association between fat-soluble vitamins and self-reported health status: a cross-sectionalanalysis of the MARK-AGE cohort. Brit J Nutr 128: 433-443, IF 3.718.

98. Ayele, D. A., Teferra, T. F., Frank, J. & Gebremedhin, S. (2022) Optimization of nutritional and functional qualities of local complementary foods of southern Ethiopia using a customized mixture design. Food Sci Nutr 10: 239-252, IF 2.863.

97. Montoya-Arroyo, A., Wagner, T., Sus, N., Müller, M., Kröpfl, A., Vetter, W. & Frank, J. (2021) Cytotoxicity, cellular uptake, and metabolism to short-chain metabolites of 11'-α-tocomonoenol is similar to RRR-α-tocopherol in HepG2 cells. Free Radic Biol Med 177: 24-30, IF 7.376. 

96. Flory, S., Sus, N., Haas, K., Jehle, S., Kienhöfer, E., Wähler, R., Adler, G., Venturelli, S. & Frank, J. (2021) Increasing post-digestive solubility of curcumin is the most successful strategy to improve its oral bioavailability: a randomized cross-over trial in healthy adults and in vitro bioaccessibility experiments. Mol Nutr Food Res 65: 2100613, IF 5.914.

95. Leischner, C., Burkard, M., Michel, A., Berchtold, S., Niessner, H., Marongiu, L., Busch, C., Frank, J., Lauer, U. M. & Venturelli, S. (2021) Comparative analysis of the antitumor activity of cis- and trans-resveratrol in human cancer cells with different p53 status. Molecules 26: 5586, IF 4.927.

94. Eleraky, L., Issa, R., Maciel, S., Mbwana, H., Rybak, C., Frank, J. & Stuetz, W. (2021) High prevalence of overweight and its association with mid-upper arm circumference among female and male farmers in Tanzania and Mozambique. Int J Environ Res Public Health 18: 9128, IF 3.390.

93. Mieres-Castro, D., Theoduloz, C., Sus, N., Burgos-Edwards, A., Schmeda-Hirschmann, H., Frank, J. & Jiménez-Aspee, F. (2022) Iridoids and polyphenols from Chilean Gaultheria spp. berries decrease the glucose uptake in Caco-2 cells after simulated gastrointestinal digestion. Food Chemistry 369: 130940, IF 7.514.

92. Sun, X., Ma, L., Lux, P.E., Wang, X., Stuetz, W., Frank, J. & Liang, J. (2022) The distribution of phosphorus, carotenoids and tocochromanols in grains of four Chinese maize (Zea mays L.) varieties. Food Chemistry 367: 130725, IF 7.514.

91. Abou-Rizk, J., Jeremias, T., Nasreddine, L., Jomaa, L., Hwalla, N., Tamim, H., Frank, J. & Scherbaum, V. (2021) The double burden of malnutrition and nutritional inadequacies amongSyrian refugee mothers with children under five years in Greater Beirut, Lebanon. Int J Environ Res Public Health 18: 6894, IF 3.390.

90. Montoya-Arroyo, A., Alfaro, J. D., Esquivel, P., Jiménez, V. M. & Frank, J. (2021) Vitamin E profiles in Acrocomia aculeata from three regions in Costa Rica. J Food Compos Anal 100: 103936, IF 4.556.

89. Jungert, A. & Frank, J. (2021) Intra-individual variation and reliability of biomarkers of the antioxidant defense system by considering dietary and lifestyle factors in premenopausal women. Antioxidants 10: 448, IF 7.675.

88. Lux, P. E., Schneider, J., Müller, F., Wiedmaier-Czerny, N., Vetter, W., Weiß, T. M., Wuerschum, T. & Frank, J. (2021) Location and Variety but Not Phosphate Starter Fertilization Influence the Profiles of Fatty Acids, Carotenoids, and Tocochromanols in Kernels of Modern Corn (Zea mays L.) Hybrids Cultivated in Germany. J Agric Food Chem 69: 2845–2854, IF 5.279.

87. Omar, N. A., Frank, J., Kruger, J., Dal Bello, F., Medana, C., Collino, M., Zamaratskaia, G., Michaelsson, K., Wolk, A. & Landberg, R. (2021) Effects of high intakes of fructose and galactose, with or without added fructooligosaccharides, on metabolic factors, inflammation, and gut integrity in a rat model. Mol Nutr Food Res 65: 2001133, IF 5.914.

86. Vollmer, K., Czerny, M., Vásquez-Caicedoa, A. L., Varona Iglesias, S., Frank, J., Carle, R. & Steingass, C. B. (2021) Non-thermal processing of pineapple (Ananas comosus [L.] Merr.) juice using continuous pressure change technology (PCT): HS-SPME-GC-MS profiling, descriptive sensory analysis, and consumer acceptance. Food Chemistry 345: 128786, IF 7.514.

85. Irías-Mata, A., Sus, N., Hug, L. M., Müller, M., Vetter, W. & Frank, J. (2020) α-Tocomonoenol is bioavailable in mice and may partly be regulated by the function of the hepatic α-tocopherol transfer protein. Molecules 25: 4803, IF 4.412.

84. Vollmer, K., Santarelli, S., Vásquez-Caicedoa, A. L., Varona Iglesias, S., Frank, J., Carle, R. & Steingass, C. B. (2020) Non-Thermal Processing of Pineapple (Ananas comosus [L.] Merr.) Juice Using Continuous Pressure Change Technology (PCT): Effects on Physical Traits, Microbial Loads, Enzyme Activities, and Phytochemical Composition. Food and Bioprocess Technology 13: 1833-1847, IF 4.465.

83. Abera, S. F., Kantelhardt, E. J., Bezabih, A., M., Tsadik, M., Lauvai, J., Ejeta, G., Wienke, A., Frank, J. & Scherbaum, V. (2020) What factors are associated with maternal undernutrition in eastern zone of Tigray, Ethiopia? Evidence for nutritional well-being of lactating mothers. BMC Public Health 20: 1214, IF 3.295.

82. Alfaro-Solís, J. D., Montoya-Arroyo, A., Jiménez, V. M., Arnáez-Serrano, E., Pérez, J., Vetter, W., Frank, J. & Lewandowski, I. (2020) Acrocomia aculeata fruits from three regions in Costa Rica: an assessment of biometric parameters, oil content and oil fatty acid composition to evaluate industrial potential. Agroforestry Systems 94: 1913-1927, IF 2.549.

81. Seiwert, N., Fahrer, J., Nagel, G., Frank, J., Behnam, D. & Kaina, B. (2021) Curcumin administered as micellar solution suppresses intestinal inflammation and colorectal carcinogenesis. Nutrition and Cancer 73: 686-693, IF 2.900.

80. Anaya, K., Podszun, M., Gadelha, C., Franco, O. L. & Frank, J. (2020) The coconut water antimicrobial peptide CnAMP1 is taken up into intestinal cells but does not alter P-glycoprotein expression and activity. Plant Foods for Human Nutrition 75: 396-403, IF 3.921.

79. Vollmer, K., Chakraborty, S., Bhalerao, P. P., Carle, R., Frank, J. & Steingass, C. B. (2020) Effect of pulsed light treatment on natural microbiota, enzyme activity, and phytochemical composition of pineapple (Ananas comosus [L.] Merr.) juice. Food and Bioprocess Technology 13:1095–1109, IF4.465.

78. Khayyal, M. T., El-Hazek,R. M., El-Sabbagh, W. A., Frank, J., Behnam, D. & Abdel-Tawab, M. (2020) Micellar solubilization enhances the anti-inflammatory effect of xanthohumol. Phytomedicine 71: 153233, IF 5.340. 

77. Kruger, J., Sus, N. & Frank, J. (2020) Ascorbic acid, sucrose and olive oil lipids mitigate the inhibitory effects of pectin on the bioaccessibility and Caco-2 cellular uptake of ferulic acid and naringenin. Food & Function 11: 4138-4145, IF 5.396.

76. Sotomayor, C. G., Minović, I., Eggersdorfer, M. L., Riphagen, I. J., de Borst, M. H., Dekker, L. H., Nolte, I. M., Frank, J., van Zon, S. K. R., Reijneveld, S. A., van der Molen, J. C., Vos, M., Kootstra-Ros, J. E., Rodrigo, R., Kema,I. P.,Navis,G. J. & Bakker, S. J. L. (2020) Duality of Tocopherol Species and Insights into the Association with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study. Nutrients 12: 580, IF 5.717.

75. Lux, P. E., Freiling, M., Stuetz, W., von Tucher, S., Carle, R., Steingass, C. B. & Frank, J. (2020) (Poly)phenols, Carotenoids, and Tocochromanols in Corn (Zea mays L.) Kernels as Affected by Phosphate Fertilization and Sowing Time. J Agric Food Chem 68: 612-622, IF 5.279.

74. Kruger, J., Stuetz, W. & Frank, J. (2019) Iron, catechin and ferulic acid inhibit β-carotene absorption in Caco-2 cells by reducing micellization. J Agric Food Chem 67: 5792-5800, IF 3.571.

73. Mahli, A., Seitz, T., Fresse, K., Weiskirchen, R., Frank, J., Abdel-Tawab, M., Behnam, D. & Hellerbrand, C. (2019) Therapeutic application of micellar solubilized xanthohumol in a Western-type diet-induced mouse model of obesity, diabetes and non-alcoholic fatty liver disease. Cells 8: 359, IF 4.829.

72. Gowele, V. F., Kinabo, J., Jumbe, T., Kirschmann, C., Frank, J. & Stuetz, W. (2019) Provitamin A Carotenoids, Tocopherols, Ascorbic Acid and Minerals in Indigenous Leafy Vegetables from Tanzania. Foods 8: 35, IF 3.011. 

71. Anaya, K., Sus, N., Gadelha, C. & Frank, J. (2019) Development validation of a rapid reversed-phase liquid chromatography method for CnAMP1 peptide quantification in human intestinal cell lines. Amino Acids 51: 407-418, IF 2.906.

70. Venturelli, S., Niessner, H., Sinnberg, T., Berger, A., Burkard, M., Urmann, C., Donaubauer, K., Böcker, A., Leischner, C., Riepl, H., Frank, J., Lauer, U.M., Garbe, C. & Busch, C. (2018) 6- and 8-Prenylnaringenin, novel natural histone deacetylase inhibitors found in hops, exert antitumor activity on melanoma cells. Cell Physiol Biochem 51: 543-556, IF 5.5.

69. Irías-Mata, A., Sus, N., Flory, S., Stock, D.,Woerner, D., Podszun, M. & Frank, J. (2018) α-Tocopherol transfer protein does not regulate the cellular uptake and intracellular distribution of α- and γ-tocopherols and -tocotrienols in cultured liver cells. Redox Biology 19: 28-36, IF 7.793.

68. Calvo-Castro, L. A., Sus, N., Schiborr, C.,Bosy-Westphal, A., Duran, M. L., Fesenmeyer, D., Fesenmeyer, G. & Frank, J. (2019) Pharmacokinetics of vitamin E, γ-oryzanol and ferulic acid in healthy humans after the ingestion of a rice bran-enriched porridge prepared with water or with milk. Eur J Nutr58: 2099-2110, IF 4.423.

67. Giller, K., Drews, B., Berard, J., Kienberger, H., Schmicke, M., Frank, J., Spanier, B., Daniel, H., Geisslinger, G. & Ulbrich, S. E. (2018) Bovine embryo elongation is altered due to maternal fatty acid supplementation. Biology of Reproduction 99: 600-610, IF 3.432.

66. Khayyal, M. T., El-Hazek, R. M., El-Sabbagh, W. A., Frank, J., Behnam, D. & Abdel-Tawab, M. (2018) Micellar solubilisation enhances the anti-inflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis. Nutrition 54: 189-196, IF 3.420.

65. Calvo-Castro, L. A., Schiborr, C., David, F., Ehrt, H., Voggel, J., Sus, N., Behnam, D., Bosy-Westphal, A., & Frank, J. (2018) The oral bioavailability of trans-resveratrol from a grapevine-shoot extract in healthy humans is significantly increased by micellar solubilization. Mol Nutr Food Res 62: 1701057, IF 4.323.

64. Calvo-Castro, L. A.,Burkard, M., Sus, N., Scheubeck, G., Leischner, C., Lauer, U. M., Bosy-Westphal, A., Hund, V., Busch, C., Venturelli, S. & Frank, J. (2018) The oral bioavailability of 8-prenylnaringenin from hops (Humulus lupulus L.) in healthy women and men is significantly higher than that of its positional isomer 6-prenylnaringenin in a randomized crossover trial. Mol Nutr Food Res 62: 1700838, IF 4.323.

63. Sus, N., Schlenz, J., Calvo-Castro, L. A., Burkard, M., Venturelli, S., Busch, C. & Frank, J.(2018) Validation of a rapid and sensitive reversed- phase liquid chromatographic method for the quantification of prenylated chalcones and flavanones in plasma and urine. NFS Journal 10: 1-9, CiteScore 4.29.

62. Irías-Mata, A., Stuetz, W., Sus, N., Hamman, S., Gralla, K., Cordero-Solano, A., Vetter, W. & Frank, J. (2017) Tocopherols, tocomonoenols and tocotrienols in oils of Costa Rican palm fruits: a comparison between six varieties and chemical vs. mechanical extraction. J Agric Food Chem 65: 7476–7482, IF 3.154.

61. Podszun, M. C., Jakobi, M., Birringer, M., Weiss, J. & Frank, J. (2017) The long chain α–tocopherol metabolite α-13’-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180. Mol Nutr Food Res 61: 1600605, IF 4.551.

60. Frank, J., Schiborr, C., Kocher, A., Meins, J., Behnam, D., Schubert-Zsilavecz, M. & Abdel-Tawab, M. (2017) Transepithelial transport of curcumin in Caco-2 cells is significantly enhanced by micellar solubilisation. Plant Foods for Human Nutrition 72: 48-53, IF 2.276.

59. Hanschke, N., Kankofer, M., Locher, L., Höltershinken, M., Meyer, U., Frank, J., Dänicke, S. & Rehage, J. (2016) The effect of conjugated linoleic acid (CLA) supplements on oxidative and antioxidative status of dairy cows. Journal of Dairy Science 99: 8090-8102, IF 2.573.

58. Hagl, S., Asseburg, H., Heinrich, M., Sus, N., Blumrich, E.-M., Dringen, R., Frank, J. & Eckert, G. P. (2016) Effects of long-term Rice Bran Extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. NeuroMolecular Medicine 18: 347-363, IF 3.678.

57. Dützmann, S., Schiborr, C., Kocher, A., Pilatus, U., Hattingen, E., Weissenberger, J., Gessler, F., Quick-Weller, J., Franz, K., Seifert, V., Frank, J. & Senft, C. (2016) Intratumoral concentrations and effects of orally administered micellar curcuminoids in glioblastoma patients. Nutr Cancer 68: 943-948, IF 2.322.

56. Kocher, A., Bohnert, L., Schiborr, C. & Frank, J. (2016) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidaemic individuals. Mol Nutr Food Res 60: 1555-1563, IF 4.551.

55. Bortel, N., Armeanu-Ebinger, S., Schmid, E., Kirchner, B., Frank, J., Kocher, A., Schiborr, C., Warmann, S.W., Fuchs, J. & Ellerkamp, V. (2015) Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB and the beta-catenin pathways. Oncotarget 6: 40680–40691, IF 6.359.

54. Hagl, S., Berressem, D., Bruns, B., Sus, N., Frank, J. & Eckert, G. P. (2015) Beneficial effects of ethanolic and hexanic rice bran extract on mitochondrial function in PC12 cells and the search for bioactive components. Molecules 20: 16524-16539, IF 2.416.

53. Hagl, S., Kocher, A., Schiborr, C., Kolesova, N., Frank, J. & Eckert, G. P. (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochemistry International 89: 234-242, IF 3.092.

52. Hagl, S., Berressem, D., Grewal, R., Sus, N., Frank, J. & Eckert, G. P. (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutritional Neuroscience 19: 1-10, IF 2.274.

51. Sadri, H., Dänicke, S., Rehage, J., Frank, J., & Sauerwein, H. (2015) Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation. Journal of Dairy Science 98: 7034-7043, IF 2.573.

50. Kocher, A., Hagl, S., Schiborr, C., Eckert, G. P., & Frank, J. (2015) Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice. NFS Journal 1: 3-8, CiteScore 1.67.

49. Kocher, A., Schiborr, C., Behnam, D. & Frank, J. (2015) The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol. J Funct Foods 14: 183-191, IF 3.574.

48. Moazzami, A. A., Frank, S., Gombert, A., Sus, N., Bayram, B., Rimbach, G., & Frank, J. (2015) Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats. Food & Function 6: 1090-1097, IF 2.907.

47. Hongsibsong, S., Stuetz, W., Sus, N., Prapamontol, T., Grune, T.,& Frank, J. (2014) Dietary exposure to continuous small doses of alpha-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats. Toxicology Reports 1: 1106-1114, CiteScore (2019) 2.73.

46. Hagl, S., Heinrich, M., Kocher, A., Schiborr, C., Frank, J. & Eckert, G. P. (2014) Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer's disease. The Journal of Prevention of Alzheimer’s Disease 1: 80-83.

45.Chin, D., Hagl, S., Höhn, A., Huebbe, P., Pallauf, K., Grune, T., Frank, J., Eckert, G. P. & Rimbach, G. (2014) Adenosine triphosphate concentrations are higher in the brain of APOE3 compared to APOE4 targeted-replacement mice and can be modulated by curcumin. Genes & Nutrition 9: 397, IF 3.329.

44. Chin, D., Huebbe, P., Frank, J., Rimbach, G. & Pallauf, K. (2014) Curcumin may impair iron status when fed to mice for six months. Redox Biology 2: 563-569, IF 6.337.

43. Podszun, M. C., Grebenstein, N., Spruss, A., Schlueter, T., Kremoser, C., Bergheim, I. & Frank, J. (2014) Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid-accumulation and down-regulate CD36 protein in the liver of guinea pigs. J Nutr Biochem 25: 573-579, IF 4.592.

42. Grebenstein, N., Schumacher, M., Graeve, L., & Frank, J. (2014) α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro. Mol Nutr Food Res 58: 1052-1060, IF 4.909.

41. Schiborr, C., Kocher, A., Behnam, D., Jandasek, J., Toelstede, S. & Frank, J. (2014) The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res 58: 516-527, IF 4.909.

40. Bayram, B., Rimbach, G., Frank, J. & Esatbeyoglu, T. (2014) A rapid method for glutathione quantification with potential application to glutathione disulfide, uric acid and ascorbic acid using high-performance liquid chromatography with coulometric electrochemical detection. J Agric Food Chem 62: 402-408, IF 2.906.

39. Mohrenz, I. V., Antonietti, P., Pusch, S., Capper, D., Balss, J., Voigt, S., Weissert, S., Mukrowsky, A., Frank, J., Senft, C., Seifert, V., vom Deimling, A., & Koegel, D. (2013) Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU- induced oxidative stress and cell death. Apoptosis 18: 1416-1425, IF 3.949.

38. Hagl, S., Kocher, A., Schiborr, C., Eckert, S., Ciobanu, I., Birringer, M., El-Askary, H., Helal, A., Khayyal, M. T., Frank, J., Müller, W. E. & Eckert, G. P. (2013) Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res 76: 17-27, IF 4.436

37. Schiborr, C., Schwamm, D., Kocher, A., Rimbach, G., Eckert, G. P. & Frank J. (2013) The senescence-accelerated mouse - prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals. Pharmacol Res 74: 113-120, IF 4.436

36. Eckert, G. P., Schiborr, C., Hagl, S., Abdel-Kader, R., Müller, W. E., Rimbach, G. & Frank, J.(2013) Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8. Neurochemistry International 65: 595-602, IF 2.857.

35. Podszun, M. C., Grebenstein, N., Hofmann, U., &Frank, J.(2013) High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs. Toxicology and Applied Pharmacology 266: 452-458, IF 4.447.

34. Bayram, B., Ozcelik, B., Frank, J. & Rimbach, G. (2013) A Validated Method for the Determination of Selected Phenolics in Olive Oil Using High-Performance Liquid Chromatography with Coulometric Electrochemical Detection and a Fused-Core Colum. Food Chemistry 138: 1663-1669, IF 3.655.

33. Bayram, B., Esatbeyoglu, T., Schulze, N., Ozcelik, B., Frank, J. & Rimbach, G. (2012) Comprehensive Analysis of Polyphenols in 55 Extra Virgin Olive Oils by HPLC-ECD and Their Correlation with Antioxidant Activities. Plant Foods for Human Nutrition 67: 326-336, IF 2.505. 

32. Bayram, B., Nikolai, S., Huebbe, P., Ozcelik, B., Grimm, S., Grune, T.,Frank, J., & Rimbach, G. (2012) Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence accelerated mouse prone 8.Age 35: 1205-1217, IF 3.948.

31. Grebenstein, N. & Frank, J. (2012) Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid-chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver. J Chromatogr A 1243: 39-46, IF 4.531.

30. Egert, S., Tereszczuk, J., Wein, S., Müller, M.J., Frank, J., Rimbach, G. & Wolffram, S. (2013) Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. Eur J Nutr 52: 281-288, IF 2.750.

29. Bayram, B., Ozcelik, B., Grimm, S., Roeder, T., Schrader, C., Ernst, I., Wagner, A., Grune, T., Frank, J. & Rimbach, G. (2012) A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Research 15: 71-81, IF 3.826.

28. Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanovic, I., Laue, C., Winkler, P., Rüfer, C., Frank, J., Boesch-Saadatmandi, C., Rimbach, G. & Schrezenmeir, J. (2013) Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. Nutrition, Metabolism and Cardiovascular Disease 23: 403-409, IF 3.731.

27. Boesch-Saadatmandi, C.,Rimbach, G., Jungblut, A. & Frank, J. (2011) Comparison of tetrahydrofuran, fetal calf serum, and Tween 40 for the delivery of astaxanthin and canthaxanthin to HepG2 cells. Cytotechnology 63: 89-98, IF 1.207.

26. Schrader, C., Schiborr, C., Frank, J. & Rimbach, G. (2011) Curcumin induces paraoxonase-1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Brit J Nutr 105: 167-170, IF 3.072.

25. Schiborr, C., Eckert, G. P., Weissenberger, J., Müller, W. E., Schwamm, D., Grune, T., Rimbach, G. & Frank, J. (2010) Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharmaceut Biotechnol 11: 861-867, IF 3.455.

24. Schiborr, C., Eckert, G. P.,Rimbach, G. & Frank, J. (2010) A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 397: 1917-1925, IF 3.841.

23. Fischer, A., Gaedicke, S., Frank, J., Döring, F. & Rimbach, G. (2010) Dietary vitamin E deficiency does not affect global and specific DNA methylation pattern in rat liver. Brit J Nutr 104: 935-940, IF 3.072.

22. Egert, S., Bosy-Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta-Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G., Wolffram, S. & Müller, M. J. (2009) Quercetin reduces systolic blood pressure and plasma oxidized LDL concentrations in overweight subjects with a high-CVD-risk phenotype: a double-blinded, placebo-controlled crossover study. Brit J Nutr 102: 1065-1074, IF 3.446.

21. Augustin, K., Frank, J., Augustin, S., Langguth, P., Öhrvik, V., Witthöft, C., Rimbach, G. & Wolffram, S. (2009) Green tea extracts lower 5-methyltetrahydrofolate in rats only at very high dietary concentrations and do not affect folate concentrations in a human pilot study. J Physiol Pharmacol 60: 103-108, IF 2.631.

20. Wiegand, H., Bösch-Saadatmandi, C., Wein, S., Wolffram, S., Frank, J. & Rimbach, G. (2010) Dietary flavonoids do not affect vitamin E status in growing rats. J Anim Phsyiol Anim Nutr 94: 307-318 , IF 1.106.

19. Gaedicke, S., Zhang, X., Huebbe, P., Boesch-Saadatmandi, C., Lou, Y., Wiswedel, I., Gardemann, A., Frank, J. & Rimbach, G. (2009) Dietary vitamin E, brain redox status and expression of Alzheimer’s disease relevant genes in rats. Brit J Nutr 102: 398-406, IF 3.446.

18. Frank, J., George, T. W., Lodge, J. K., Rodriguez-Mateos, A., Spencer, J. P. E., Minihane, A. M., & Rimbach, G. (2009) Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease-risk biomarkers in healthy men. J Nutr 139: 58-62, IF 3.647.

17. Gaedicke, S., Zhang, X., Schmelzer, C., Lou, Y., Doering, F., Frank, J. & Rimbach, G. (2008) Vitamin E dependent microRNA regulation in rat liver. FEBS Letters 582: 3542-3546, IF 3.264.

16. Egert, S., Wolffram, S., Bosy-Westphal, A., Bösch-Saadatmandi, C., Wagner, A., Frank, J., Rimbach, G. & Müller, M. J. (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138: 1615-1621, IF 3.647.

15. Frank, J., Lee, S., Leonard, S. W., Atkinson, J. K., Kamal-Eldin, A. & Traber, M. G. (2008) Sex differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am J Clin Nutr 87: 1723-1729, IF 6.740.

14. Augustin, K., Blank, R., Boesch-Saadatmandi, C., Frank, J., Wolffram, S. & Rimbach, G. (2008) Dietary green tea polyphenols do not affect vitamin E-status, antioxidant capacity and meat quality of growing pigs. J Anim Physiol Anim Nutr 92: 705-711, IF 0.911.

13. Jofre-Monseny, L., Huebbe, P., Stange, I., Boesch-Saadatmandi, C., Frank, J., Jackson, K., Minihane, A. M. & Rimbach, G. (2007) Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein in apoE3 and apoE4 targeted replacement mice. Brit J Nutr 100: 44-53, IF 2.339.

12. Moazzami, A. A., Frank, J., Lundh, T., Vessby, B. & Kamal-Eldin, A. (2007) Dietary Phytosterols Inhibit the Lipid Modulating Effects of Sesamin in Rats. Curr Topics Nutraceut Res 5: 93-98, IF 0.529.

11. Frank, J., Budek, A., Lundh, T., Parker, R. S., Swanson, J. E., Lourenco, B., Gago, J., Laranjinha, J., Vessby, B. & Kamal-Eldin, A. (2006) Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro. J Lipid Res 47: 2718-2725, IF 4.357.

10. Hundhausen, C., Frank, J., Rimbach, G., Stoecklin, E., Muller, P. Y. & Barella, L. (2006) Effect of Vitamin E on Cytochrome P450 mRNA Levels in Cultured Hepatocytes (HepG2) and in Rat Liver. Cancer Genomics & Proteomics 3: 183-190.

9. Müller, P.Y., Netscher, T., Frank, J., Stöcklin, E., Rimbach, G., & Barella, L. (2005) Comparative Quantification of Pharmacodynamic Parameters of Chiral Compounds by Global Gene Expression Profiling. J Plant Physiol 162: 811-817, IF 1.403.

8. Frank, J., Kamal-Eldin, A. & Traber, M. G. (2004) Consumption of Sesame Oil Muffins Decreases the Urinary Excretion ofγ-Tocopherol Metabolites in Humans. Ann N Y Acad Sci 1031: 365-367, IF 1.789.

7. Frank, J., Eliasson, C., Leroy-Nivard, D., Budek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats. Brit J Nutr 92: 169-176, IF 2.710.

6. Frank, J., Sundberg, B., Kamal-Eldin, A., Vessby, B. & Åman, P. (2004) Yeast-Leavened Oat Breads with High or Low Molecular Weight β-Glucan Do Not Differ in Their Effects on Blood Concentrations of Lipids, Insulin, or Glucose in Humans. J Nutr 134: 1384-1388, IF 3.245.

5. Ross, A. B., Chen, Y., Frank, J., Swanson, J. E., Parker, R. S., Kozubek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Cereal Alkylresorcinols Elevate γ-Tocopherol Levels in Rats and Inhibit γ-Tocopherol Metabolism In Vitro. J Nutr 134: 506-510, IF 3.245.

4. Frank, J., Lundh, T., Parker, R. S., Swanson, J. E., Vessby, B. & Kamal-Eldin, A. (2003) Dietary (+)-Catechin and BHT Markedly Increase α-Tocopherol Concentrations in Rats by a Tocopherol-ω-Hydroxylase-Independent Mechanism. J Nutr 133: 3195-3199, IF 3.321.

3. Frank, J., Kamal-Eldin, A., Razdan, A., Lundh, T. & Vessby, B. (2003) The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenic acid increase vitamin E and cholesterol concentrations in Sprague-Dawley rats. J Agric Food Chem 51: 2526-2531, IF 2.102.

2. Frank, J., Kamal-Eldin, A., Lundh, T., Määttä, K., Törrönen, R. & Vessby, B. (2002) Effects of Dietary Anthocyanins on Tocopherols and Lipids in Rats. J Agric Food Chem 50: 7226-7230, IF 1.915.

1. Kamal-Eldin, A., Frank, J., Razdan, A., Tengblad, S., Basu, S. & Vessby, B. (2000) Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 35: 427-435, IF 1.769.

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